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A Pharmacokinetic Analysis and Pharmacogenomic Study of 6-mercaptopurine

  • Sivolapenko G
International Journal of Pharmaceutical Sciences and Developmental Research (2015) 002-007
DOI: 10.17352/ijpsdr.000002
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Abstract

Background: The efficacy and safety of 6-mercaptopurine (6-MP) therapy rely on the concentration of its metabolites. The aim of the current study is the pharmacokinetic analysis of 6-MP and the detection of its metabolites as well as the role of Thiopurine S-methyl transferase (TPMT), the enzyme associated with 6-MP metabolism, as a pharmacogenomics biomarker.

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APA

Sivolapenko, G. (2015). A Pharmacokinetic Analysis and Pharmacogenomic Study of 6-mercaptopurine. International Journal of Pharmaceutical Sciences and Developmental Research, 002–007. https://doi.org/10.17352/ijpsdr.000002

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