Abstract
We describe here the development of a photoreleasable version of a protein phosphatase-1 (PP1)-disrupting peptide (PDP-Nal) that triggers protein phosphatase-1 activity. PDP-Nal is a 23 mer that binds to PP1 through several interactions. It was photocaged on a tyrosine residue, which required the exchange of phenylalanine in PDP-Nal to tyrosine in order to disrupt the most important binding interface. This PDP-caged can be light-controlled in live cells.
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CITATION STYLE
Trebacz, M., Wang, Y., Makotta, L., Henschke, L., & Köhn, M. (2020). Development of a Photoactivatable Protein Phosphatase-1-Disrupting Peptide. Journal of Organic Chemistry, 85(3), 1712–1717. https://doi.org/10.1021/acs.joc.9b02548
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