Posterior spinal instrumented fusion for idiopathic scoliosis in patients with multisystemic neurodegenerative disorder: A report of two cases

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Abstract

Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke (MELAS) syndrome is a progressive multisystemic neurodegenerative disorder. MELAS syndrome impairs oxidative phosphorylation and predisposes patients to lactic acidosis, particularly under metabolic stress. We report 2 siblings with MELAS-associated idiopathic scoliosis who underwent posterior spinal instrumented fusion with measures taken to minimise anaesthetic and surgical stress, blood loss, and operating time.

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Loh, K. W., Chan, C. Y. W., Chiu, C. K., Hasan, M. S. B., & Kwan, M. K. (2016). Posterior spinal instrumented fusion for idiopathic scoliosis in patients with multisystemic neurodegenerative disorder: A report of two cases. Journal of Orthopaedic Surgery, 24(2), 273–277. https://doi.org/10.1177/1602400231

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