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HLA class I as a predictor of clinical prognosis and CTL infiltration as a predictor of chemosensitivity in ovarian cancer

OncoImmunology (2015) 4(5)
DOI: 10.1080/2162402X.2015.1005507
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Abstract

Cytotoxic T lymphocytes (CTLs) recognize the human leukocyte antigen (HLA) class I and antigenic peptide complex, and they play a crucial role in cancer immunity. Our recent study revealed that HLA class I downregulation is related to poorer prognosis and a low level of intratumoral CTLs is associated with platinum resistance, indicating the significance of immunological surveillance.

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Hirohashi, Y., Torigoe, T., Mariya, T., Kochin, V., Saito, T., & Sato, N. (2015). HLA class I as a predictor of clinical prognosis and CTL infiltration as a predictor of chemosensitivity in ovarian cancer. OncoImmunology, 4(5). https://doi.org/10.1080/2162402X.2015.1005507

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