Outbreak of acute enterovirus intestinal infection in Sakhalin region in August 2010

Abstract

The investigation of cases of acute intestinal infections in the Sakhalin region of Russia in August, 2010 is described. Epidemiological and molecular biological studies were conducted. After initial PCR screening and determining the nucleotide sequences of the positive samples the following enteroviruses were found: Coxsackie A2 - 42 samples (45%), Coxsackie A4 - 31 sample (34%), Enterovirus 71 - 6 samples (6,5%), Coxsackievirus B5 - 6 samples (6,5%), Coxsackie B3 - 4 samples (4%) and Coxsackie B1 - 4 samples (4%). The phylogenetic analysis of sequences showed that the closest analogues for the nucleotide sequences of these genotypes were previously identified in Japan, Korea and China in 2000-2010.