The quest for the elusive causative SNP

Abstract

El Kares et al. present evidence that fetal genetic variation in the 3′ end of ALDH1A2 may influence nephrogenesis and blood retinoic acid levels. This may be correct, but only replication of this association, ideally accounting for both the fetal and the maternal genotypes, will provide a better understanding of the biology that underlies the association. © 2010 International Society of Nephrology.