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Opsonophagocytic assay to evaluate immunogenicity of nontyphoidal salmonella vaccines

Clinical and Vaccine Immunology (2016) 23(6) 520-523
DOI: 10.1128/CVI.00106-16
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Abstract

Nontyphoidal Salmonella (NTS) invasive infections are an important cause of morbidity and mortality in sub-Saharan Africa. Several vaccines are in development to prevent these infections. We describe an NTS opsonophagocytic killing assay that uses HL-60 cells and baby rabbit complement to quantify functional antibodies elicited by candidate NTS vaccines.

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Ramachandran, G., Boyd, M. A., MacSwords, J., Higginson, E. E., Simon, R., Galen, J. E., … Tennant, S. M. (2016). Opsonophagocytic assay to evaluate immunogenicity of nontyphoidal salmonella vaccines. Clinical and Vaccine Immunology, 23(6), 520–523. https://doi.org/10.1128/CVI.00106-16

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