A STUDY OF ANALGESIC AND ANTIMICROBIAL POTENTIAL OF MITRAGYNA PARVIFOLIA

Abstract

The present study was designed to evaluate the analgesic and antimicrobial activities of ethanolic extract of leaves ofMitragyna parvifolia plant (Rubiaceae) family. The analgesic activity was carried out on swiss albino male mice by Eddy’shot plate and Acetic acid induced writhing test. The extract showed only moderate analgesic potential in acetic acidinduced writhing test at all the test doses while the extract at the dose of 500 mg/kg (P<0.01) showed strong analgesicactivity comparable to standard drug Diclofenac sodium (50 mg/Kg, i.p.) in hot plate method. The extract in differentconcentrations was also tested for antibacterial activity using agar well diffusion method. The extract significantlyinhibited S. aureus and showed some degree of inhibition against P. aeruginosa and E. coli.