CKI, there's more than one: Casein kinase I family members in Wnt and Hedgehog signaling

Abstract

Multiple members of the casein kinase I family of serine/threonine protein kinases are involved in positive and negative roles in Wnt and Hedgehog signaling. Here I review these roles, including recent results on casein kinase I (CKI) phosphorylation and activation of LRP6, and CKI phosphorylation of Ci and mediation of Ci-Slimb/β-TrCP binding. © 2006 by Cold Spring Harbor Laboratory Press.