Preparation of Crosslinked Alginate Hydrogels for the Adsorption and Sustainable Release of Doxorubicin Hydrochloride

Abstract

Since it is expensive and takes considerable time to synthesize a new drug or improve an old one, a drug carrier can be used instead for control and targeted release of the drug. In this study, hydrogel beads were used as drug carriers for the controlled release of doxorubicin hydrochloride. Aiming to incorporate doxorubicin hydrochloride into hydrogel, various metal crosslinked alginate beads were prepared. Doxorubicin hydrochloride was incorporated by adsorption into the beads and studied the factors affecting the adsorption of drug onto the hydrogel beads. The results showed that ferric crosslinked alginate (Fe(III)–Alg) and stannous crosslinked alginate (Sn-Alg) hydrogel beads had a better adsorption percentage which was more than 21%. The amount of hydrogel, time, drug concentration, and pH of the solution all influenced the adsorption percentage. Hence, the adsorption was the best at neutral pH after 24 h when 100 mg of Fe(III)–Alg was added to the drug. Moreover, the release of the drug at different body simulation pH was investigated. The time and pH of the solution influenced the drug release where maximum drug release percentage was 82.822% after 25 h when the solution’s pH was 1.52. This system is assumed to follow the Higuchi kinetic release model.