Plasma proteomics for cognitive decline and dementia—A Southeast Asian cohort study

Abstract

INTRODUCTION: The prognostic utility of plasma proteomics for cognitive decline and dementia in a Southeast Asian population characterized by high cerebrovascular disease (CeVD) burden is underexplored. METHODS: We examined this in a Singaporean memory clinic cohort of 528 subjects (n = 300, CeVD; n = 167, incident cognitive decline) followed-up for 4 years. RESULTS: Of 1441 plasma proteins surveyed, a 12-protein signature significantly predicted cognitive decline (q-value