AB1150 ORDER OF APPEARANCE OF PSORIASIS AND ARTHRITIS SYMPTOMS IN PSORIATIC ARTHRITIS: COMPARATIVE STUDY OF A RETROSPECTIVE COHORT

Abstract

Background Little is known about the chronologic order of appearance of psoriasis (Pso) and psoriatic arthritis (PsA) symptoms and its effect on disease evolution. Most information is based on population-based registries or big data that may lack precision. Objectives To evaluate duration and chronologic order of appearance cutaneous and articular manifestations of PsA from 1st symptoms till diagnosis.To compare differences between patients with symptoms and diagnosis of Pso before PsA with those that manifest Pso after PsA. Methods A retrospective cohort study was conducted. Eligible patients were 219 patients that met ASAS criteria visited the SpA clinic between July – October 2022. Finally, 129 patients that met CASPAR criteria and Pso diagnosis were included. Other autoimmune rheumatic diseases were excluded. Data were collected previously reviewing patient records available from the electronic and paper database of the hospital. Additional information was retrieved by the shared medical history database of the Catalan Institute of Health which attends the 99.2% of the population. Missing data were collected prospectively by patient interview. ANOVA or Kruskall-Wallis test was carried out according to variable distribution. Results A total of 129 patients were included from which 98 had all time data related about disease appearance. There were 13.3% of missing data. The median disease evolution in years was 14 years with patients from 1 to 53 years of duration. The description and comparison of the clinical characteristics of each group is summarized in Table 1.Patients that begin with arthritis showed significant association with higher elevated C reactive protein and longer PsA disease duration. Longer time till arthritis appearance as well as more prevalence of Dactylitis was more observed in patients that begin with Pso before arthritis.View this table:View inline View popup Conclusion Significantly higher prevalence of CRP elevation in patients that begin with arthritis.Higher prevalence of dactylitis and longer time until articular manifestation was observed in patients that begin with Pso. Reference [1]J Am Acad Dermatol. 2019 Dec;81(6):1283-1291. Acknowledgements: NIL. Disclosure of Interests None Declared.