Synthesis and antimicrobial activity of some flavanone derivatives

Abstract

Flavanone has been used widely for their antimicrobial and antifungal property. The Chalcones were reported by Claisen-Schmidt condensation of substituted acetophenone with substituted aromatic aldehydes. Various analogs of flavanone were synthesized from by oxidative cyclization of chalcones with satisfactory yield and purity. All the title compounds characterized on the basis of their IR, 1H NMR, Mass spectroscopic data. All analogues of 2,3-dihydro-2-phenylchromen-4-one have shown moderate to good antimicrobial and antifungal property by the Filter paper disc method.