Neurofibromatosis phaeochromocytoma, and somatostatinoma

Abstract

A case of a triple tumor in a 49 yr old woman is described: somatostatinoma, neurofibromatosis and pheochromocytoma. Eight cases of somatostatinoma have been described. The influence of somatostatin on the endocrine and digestive systems has been discussed by Krejs et al. Cholelithiasis was found in five of six cases reviewed and was apparently due to depression of cholecystokinin-pancreozymin secretion. Diabetes was present in all patients, presumably because of inhibition of insulin activity. The postoperative hypoglycaemia in our patient was possibly due to removal of this inhibition.