Phosphorylation of IκBβ at serine 32 by T-lymphokine-activated killer cell-originated protein kinase is essential for chemoresistance against doxorubicin in cervical cancer cells

Abstract

Background: The regulatory mechanism of TOPK underlying cancer cell survival remains unknown. Results: TOPK directly interacts with and phosphorylates IκBβ at Ser-32. Conclusion: TOPK is a critical mediator of cervical cancer chemoresistance in response to doxorubicin. Significance: This study provides new insight on role of TOPK in cervical cancer cell survival in response to doxorubicin. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.