Synthesis of fine chemicals by the conjugate addition of nitroalkanes to electrophilic alkenes

Abstract

Several aliphatic nitro compounds have been employed as stabilized carbanions in the conjugate addition to a variety of electron-poor alkenes (Michael reaction). Depending on the nature of the alkene, new carbon-carbon single or double bonds can be generated. However, all the Michael adducts can be efficiently utilized as key building blocks for the synthesis of a huge array of fine chemicals, including homo- and heterocyclic structures. © 2006 IUPAC.