Role of interleukin-6 in T-cell activation during primary and secondary infection with Listeria monocytogenes

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Abstract

Injection of recombinant interleukin-6 (IL-6) into mice enhances recovery from infection with Listeria monocytogenes. In this study, the role of IL-6 during primary and secondary Listeria infection was further tested. Neutralization of IL-6 by polyclonal antibody exacerbated primary infection and significantly delayed gamma interferon production by cultured spleen cells. In contrast, administration of anti-IL-6 antibody at the time of secondary infection did not affect the recovery of mice from infection or gamma interferon production, showing that activated T cells are not dependent on IL-6.

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Liu, Z., Simpson, R. J., & Cheers, C. (1995). Role of interleukin-6 in T-cell activation during primary and secondary infection with Listeria monocytogenes. Infection and Immunity, 63(7), 2790–2792. https://doi.org/10.1128/iai.63.7.2790-2792.1995

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