Neutrophils and Neutrophil-Based Drug Delivery Systems in Anti-Cancer Therapy

Abstract

Neutrophils, a type of immune cell, may play a complex role in cancer and can have completely opposite effects. In fact, while they can help fight tumors by attacking cancer cells, they can also help tumors grow by creating a supportive environment. Scientists are exploring ways to either block neutrophils that help cancer grow, activate the anti-tumorigenic functions of neutrophils or use them to deliver cancer-fighting drugs. This review discusses the different ways neutrophils interact with tumors and highlights new strategies that could turn them into powerful tools for anti-cancer therapy.