The Association of Irisin with the Progression of Diabetes Mellitus Irisin and Diabetes Progression

Abstract

Introduction: There is an ongoing debate over the involvement of irisin in the glucose metabolism. In this study, we aimed to see the association of irisin with the markers of glucose intolerance. Materials and Methods: We analyzed the relation of irisin with metabolic markers such as Homeostatic Model Assessment-Insulin Resistance (HOMA-IR), insulin, and glucose in 152 subjects, subdivided into normal, impaired glucose tolerance and diabetic subgroups. Results: We found that the irisin levels of individuals with different stages of glucose intolerance did not show any significant difference. There was not any correlation between irisin levels with HOMA-IR. However, we observed a positive and significant correlation between circulating irisin concentrations and 120-minute glucose, 120-minute insulin, and HbA1c levels. Conclusion: The conclusive results of this study are that irisin could be somehow associated with insulin resistance but do not show a significant difference with neither diabetes nor different stages of insulin resistance.