Susceptibilidad in vitro a anidulafungina en 100 cepas de especies de Candida aisladas previo a la introducción de esta equinocandina en Chile

Abstract

Fungi, particularly yeasts, have become important opportunistic pathogens that can be resistant to antifungal agents or develop resistance. To address this problem, new molecules such as echinocandins, have been developed. Susceptibility to anidulafungin was studied in yeasts isolated previous to the introduction of this drug in Chile. One hundred strains of different yeast species isolated from invasive fungal infections during 2007 and 2008 were studied. Susceptibility testing of anidulafungin was performed by broth microdilution according to CLSI. All strains were susceptible to anidulafungin. MIC 50 and MIC 90 were 0.125 μg/mL and 1 μg/mL, respectively. Compared to other yeasts, C. parapsilosis showed a slight increase in the MICs for anidulafungin (MIC 50, 1 μg/mL, MIC 90, 2 μg/mL), but remained within the susceptible range. Both, fluconazole resistant (8) and dose dependant susceptible strains (16) were susceptible to anidulafungin. In vitro, this echinocandin appears to be an effective therapeutic alternative.