Cell wall active antifungal compounds produced by the marine fungus Hypoxylon oceanicum LL-15G256. I. Taxonomy and fermentation

Abstract

The cell wall targeted antifungal activity of Hypoxylon oceanicum LL-15G256 extracts resulted from the production of novel lipodepsipeptides and previously reported macrocyclic polylactones. In an optimized medium, titers of the lipodepsipeptide and the polylactones reached approximately 200~400 mg/liter and 25~50 mg/liter, respectively. The optimum fermentation temperature for production of 15G256γ was 28°C. Seawater appeared to have an inhibitory effect on metabolite accumulation at lower fermentation temperatures.