Abstract
The AAV2.5T vector evolved to transduce human-airway epithelium, but a preclinical animal model to evaluate this virus had not yet been identified. We show that AAV2.5T also effectively transduces ferret airway epithelium in vitro and lungs in vivo, but neutralizing antibodies limited the efficacy of repeat dosing in juvenile, but not neonatal, ferrets.
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Tang, Y., Yan, Z., Lin, S., Huntemann, E. D., Feng, Z., Park, S. Y., … Engelhardt, J. F. (2020). Repeat Dosing of AAV2.5T to Ferret Lungs Elicits an Antibody Response That Diminishes Transduction in an Age-Dependent Manner. Molecular Therapy Methods and Clinical Development, 19, 186–200. https://doi.org/10.1016/j.omtm.2020.09.008
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