Atividade antiinflamatória do extrato aquoso de Arrabidaea chica (Humb. & Bonpl.) B. Verl. sobre o edema induzido por venenos de serpentes amazônicas

Abstract

The study investigated the anti-inflammatory effects of the aqueous extract (EAq), the Arrabidaea chica (Humb. & Bonpl.) B. Verl., Bignoniaceae, known as the "crajiru", tested on the paw oedema induced in inflammatory process by venoms Amazon snakes from the Bothrops and Crotalus species, on albino mice. This process was done by an oral, intraperitoneal and subcutaneous way. The cushions thickness was measured at time breaks of 1, 3, 6, 12 and 24 hours, Bothrops genus and 1, 3 and 6 hours, Crotalus genus, and a histopathologic analysis was made. The Bothrops genus, was used as an inhibitory effect for the subcutaneous and intraperitoneal way (12 hours), and it had an inhibition of 55.87% and 65.70%, respectively. For the Crotalus genus, the inhibitory effect for the subcutaneous way after 3 hours was the 33.55% and 79.81%, after 6 hours. The intraperitoneal way affect after 3 hours had an inhibition of 48.02% and 92.52% after 6 hours. For the histopathological analysis, the leucocytes infiltration and the miocitolisis were the most expressive parameters and thus inhibited. The results suggest the presence of active principles with anti-inflammatory effects.