In vitro anthelmintic properties of Buchholzia coriaceae and Gynandropsis gynandra extracts

Abstract

Methanol extracts from the leaves and stems of Gynandropsis gynandra and Buchholzia coriaceae were investigated for their activity against Fasciola gigantica, Taenia solium and Pheritima pasthuma, respectively. Five concentrations (10-100 mg/ml) of each extract were studied in the bioassay, which involved determination of time of paralysis and time of death of the worms. All the extracts exhibited considerable anthelmintic activities, and the order of sensitivity of the extracts to the worms was P. pasthuma > F. gigantica > T. solium. The most active of the extracts were B. coriaceae and G. gynandra stem methanol extracts. Piperazine citrate (10 mg/ml) and distilled water were included in the assay as standard reference drug and control, respectively.