Human DNA tumor viruses evade uracil-mediated antiviral immunity

Abstract

Most DTV’s establish persistence in the human host and AID/A3 proteins have not effectively achieved uracil-mediated antiviral immunity and instead are potentially being utilized by DTVs to evolve and promote immune escape. Notably, there are several recent studies suggesting that the A3 proteins are promoting the evolution and viral fitness of SARS-CoV-2 [52,53]. Even more dangerous is the threat to the host genome, which could promote cellular transformation and cancer. For this reason, there is considerable effort toward developing therapeutics to inhibit these proteins [54].