The influence of the precuneus on the medial temporal cortex determines the subjective quality of memory during the retrieval of naturalistic episodes

Abstract

Memory retrieval entails dynamic interactions between the medial temporal lobe and areas in the parietal and frontal cortices. Here, we tested the hypothesis that effective connectivity between the precuneus, in the medial parietal cortex, and the medial temporal cortex contributes to the subjective quality of remembering objects together with information about their rich spatio-temporal encoding context. During a 45 min encoding session, the participants were presented with pictures of objects while they actively explored a virtual town. The following day, under fMRI, participants were presented with images of objects and had to report whether: they recognized the object and could remember the place/time of encoding, the object was familiar only, or the object was new. The hippocampus/parahippocampus, the precuneus and the ventro-medial prefrontal cortex activated when the participants successfully recognized objects they had seen in the virtual town and reported that they could remember the place/time of these events. Analyses of effective connectivity showed that the influence exerted by the precuneus on the medial temporal cortex mediates this effect of episodic recollection. Our findings demonstrate the role of the inter-regional connectivity in mediating the subjective experience of remembering and underline the relevance of studying memory in contextually-rich conditions.