Prelox® for Improvement of Erectile Quality

Abstract

Sexual desire typically persists when men grow older although their ability to attain and maintain erections sufficient to permit satisfactory sexual intercourse gradually declines. Decreasing erectile quality is a common age-related problem affecting the lives of both men and their partners. Lifestyle plays an important role in the onset of erectile quality problems, and timely improvements such as a healthier diet and exercise may significantly slow the progression to erectile dysfunction with increasing age. Essentially, all cardiovascular risk factors – including hypertension, dyslipidaemia, hyperglycaemia, obesity and cigarette smoking – impair endothelial function, which in turn directly translates into declining erectile function. In this regard a man’s penis does indeed represent a barometer indicating his cardiovascular health status. Once endothelial function has declined to a point where its restoration is not feasible, pharmacological interventions with phosphodiesterase-5 (PDE5) inhibitors may temporarily bypass physiological processes so that affected men may still enjoy sexual intercourse. A timely intervention that helps to restore endothelial function will have the advantage of preserving a man’s ability to spontaneously respond to sexual arousal. Prelox®, a patented complex formulation consisting of Pycnogenol® and L-arginine aspartate, has been demonstrated in four clinical trials to naturally restore healthy erectile quality in men presenting with moderate erectile problems. Pycnogenol, a key component of Prelox, was shown in human pharmacological studies to act as a catalyst on endothelial nitric oxide (NO) synthase for amplified synthesis of NO, the initial mediator for triggering an erection. Its combination with the enzyme’s substrate, L-arginine, synergistically increases synthesis of NO, the key component involved in vasodilatation for improved blood flow to engorge the penis. According to reviewed clinical trials, Prelox will help men with moderate erectile problems to regain healthy erectile function, greater confidence to initiate and sustain erections and more frequent morning erections. As a result of higher intercourse frequency, men taking Prelox developed significantly higher plasma testosterone values. Prelox is a safe, well-tolerated and efficacious treatment for mild to moderate cases of declining erectile quality.