Association of Systemic Lupus Erythematosus with Dyslipidemia

Abstract

Objective: To find out the association between Systemic Lupus Erythematosus (SLE) disease activity and lipid profile of patients. Study Design: Cross Sectional Study. Place and Duration of Study: Khyber Teaching Hospital, Peshawar Pakistan, from May 2023 to Feb 2024. Methodology: Seventy-eight patients of Systemic Lupus Erythematosus (SLE), were recruited using non-probability consecutive. Apart from patient demographics, SLE disease activity was calculated, and lipid profiles were sent to hospital laboratory sent to hospital laboratory. Correlation between SLE disease activity and different parameters was checked. Results: Our study of 78 patients revealed a predominantly female population 63(80.7%) with moderate disease activity 54(69.2%). Notably, abnormal lipid profiles were observed, with significant positive correlations found between SLE Disease Activity Index (SLEDAI) and Total Cholesterol (r=0.702, p=<0.001), Triglycerides (r=0.238, p=0.038), and Low-Density Lipoprotein (LDL) (r=0.633, p=<0.001). High-Density Lipoprotein (HDL) exhibited a non-significant correlation (r=0.074, p=0.519), while duration of disease showed minimal impact (r=-0.045, p=0.699). Conclusion: The study demonstrated a significant correlation between SLE Disease Activity Index (SLEDAI) and total cholesterol, low density lipoproteins and triglycerides.