The stereostructure of candicidin D

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Abstract

The candicidin D stereostructure was established based on NMR studies including DQF-COSY, ROESY, HSQC and HMBC experiments. The relative configurations of the candicidin D stereogenic centers were assigned as the following: 9R∗, 11S∗, 13S∗, 15R∗, 17S∗, 18R∗, 19S∗, 21R∗, 36S∗, 37R∗, 38S∗, 40S∗ and 41S∗. The geometry of the heptaene chromophore was defined as 22E, 24E, 26Z, 28Z, 30E, 32E and 34E.

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Szwarc, K., Szczeblewski, P., Sowiński, P., Borowski, E., & Pawlak, J. (2015). The stereostructure of candicidin D. Journal of Antibiotics, 68(8), 504–510. https://doi.org/10.1038/ja.2015.17

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