Inflammatory markers in middle-aged obese subjects: Does obstructive sleep apnea syndrome play a role?

Abstract

Background. Obstructive Sleep Apnea Syndrome (OSAS) is associated with inflammation, but obesity may be a confounding factor. Thus, the aim of this study was to explore differences in serum levels of inflammation markers between obese individuals with or without OSAS. Methods. Healthy individuals (n=61) from an outpatient obesity clinic were examined by polysomnography and blood analysis, for measurement of TNF- , IL-6, CRP, and fibrinogen levels. According to Apnea-Hypopnea Index (AHI), participants were divided into two BMI-matched groups: controls (AHI15/h, n=23) and OSAS patients (AHI ≥ 15/h, n=38). Results. OSAS patients had significantly higher TNF- levels (P