Partial response to anakinra in life-threatening Henoch-Schönlein purpura: Case report

Abstract

Henoch-SchÖnlein purpura is one of the most common forms of systemic vasculitis of childhood. We report the response to anakinra, the interleukin-1 receptor antagonist, in a 9 year old girl without prior medical problems who developed life-threatening Henoch-SchÖnlein vasculitis that produced renal failure, pulmonary hemorrhage and vasculitis of the brain. Her response supports the theory that interleukin-1 may be an important mediator in this disease. Further study of interleukin-1 antagonists in severe Henoch-Schönlein purpura may be warranted. © 2011 Boyer et al; licensee BioMed Central Ltd.