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Tautomerism in drug discovery

Journal of Computer-Aided Molecular Design
DOI: 10.1007/s10822-010-9359-z
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Abstract

The influence of tautomerism on the precise structure of drugs and thus of their potential to interact with biological systems is discussed from thermodynamic and kinetic aspects. The types of tautomerism encountered in the structure of drugs in current use are surveyed together with the effect of pH, solvent polarity, and temperature. © Springer Science+Business Media B.V. 2010.

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Katritzky, A. R., Dennis Hall, C., El-Gendy, B. E. D. M., & Draghici, B. (2010). Tautomerism in drug discovery. Journal of Computer-Aided Molecular Design. Springer Netherlands. https://doi.org/10.1007/s10822-010-9359-z

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