MicroRNA roles in the NF-κB signaling pathway during viral infections

Abstract

NF-B signaling network is a crucial component of innate immunity. miRNAs are a subtype of small noncoding RNAs, involved in regulation of gene expression at the posttranscriptional level. Increasing evidence has emerged that miRNAs play an important role in regulation of NF-B signaling pathway during viral infections. Both host and viral miRNAs are attributed to modulation of NF-B activity, thus affecting viral infection and clearance. Understandings of the mechanisms of these miRNAs will open a direction for development of novel antivirus drugs. © 2014 Zeqian Gao et al.