Formulation and evaluation of fast disintegrating tablets of domperidone using chitosan-glycine conjugates as superdisintegrant

Abstract

Purpose: The present research was envisaged to employ chitosan-glycine conjugates as superdisintegrant for developing fast disintegrating tablets of domperidone. Materials and Methods: Chitosan-glycine conjugates were prepared by physical mixing and microwave-assisted technique. Micromeritic study, Fourier transform infrared, scanning electron microscopy, and X-ray diffraction methods were employed for characterizing the powdered conjugates. The formulated FDTs were evaluated for wetting time, water absorption ratio, disintegration time, in vitro drug release, and other tablet parametric tests. Results and Discussion: The effective pore radius of unadulterated chitosan was found to be 18.45±1.27 µm whereas the chitosan-glycine conjugates prepared by physical technique and microwave technique showed effective pore radius in the range of 21.26±0.96–24.22±2.35 µm and 27.14±3.02–31.55± 2.81 µm, respectively. Conjugates prepared by both the techniques were found to have great powder flow properties. Intermolecular bridging between chitosan and glycine was held responsible for the increased swelling potential and tablet superdisintegrant property of the conjugates. The results of wetting time, water absorption ratio, and disintegration time were found to extend from 33±1.14 to 78±1.13 s, 40±0.11 to 86±0.04 %, and 21±3 to 85±3 s, respectively. Conclusion: Conjugates of chitosan with glycine have significant tablet superdisintegrant potential and can be used for developing fast disintegrating formulations.