Case Report: Convalescent Plasma Achieves SARS-CoV-2 Viral Clearance in a Patient With Persistently High Viral Replication Over 8 Weeks Due to Severe Combined Immunodeficiency (SCID) and Graft Failure

Verena Keitel; Johannes Georg Bode; Torsten Feldt; Andreas Walker; Lisa Müller; Anselm Kunstein; Caroline Klindt; Alexander Killer; Tina Senff; Jörg Timm; Philipp Ostermann; Maximilian Damagnez; Nadine Lübke; Ortwin Adams; Heiner Schaal; Gerald Antoch; Jennifer Neubert; Philipp Albrecht; Sven Meuth; Saskia Elben; Annemarie Mohring; Johannes C. Fischer; Edwin Bölke; Manfred Hoenig; Ansgar S. Schulz; Tom Luedde; Björn Jensen

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Case Report: Convalescent Plasma Achieves SARS-CoV-2 Viral Clearance in a Patient With Persistently High Viral Replication Over 8 Weeks Due to Severe Combined Immunodeficiency (SCID) and Graft Failure

Frontiers in Immunology (2021) 12

DOI: 10.3389/fimmu.2021.645989

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Abstract

We describe the unique disease course and cure of SARS-CoV-2 infection in a patient with SCID and graft failure. In absence of a humoral immune response, viral clearance was only achieved after transfusion of convalescent plasma. This observation underscores the necessity of the humoral immune response for SARS-CoV-2 clearance.

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Keitel, V., Bode, J. G., Feldt, T., Walker, A., Müller, L., Kunstein, A., … Jensen, B. (2021). Case Report: Convalescent Plasma Achieves SARS-CoV-2 Viral Clearance in a Patient With Persistently High Viral Replication Over 8 Weeks Due to Severe Combined Immunodeficiency (SCID) and Graft Failure. Frontiers in Immunology, 12. https://doi.org/10.3389/fimmu.2021.645989

Case Report: Convalescent Plasma Achieves SARS-CoV-2 Viral Clearance in a Patient With Persistently High Viral Replication Over 8 Weeks Due to Severe Combined Immunodeficiency (SCID) and Graft Failure

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