Pilot phase IB clinical trial of an alhydrogel-adsorbed recombinant ricin vaccine

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Abstract

There is no FDA-approved vaccine for the potent plant toxin ricin. We have developed a recombinant ricin vaccine, RiVax. Without adjuvant it is safe and immunogenic in mice, rabbits, and humans. Based on our studies in mice, we now report the results of a small clinical trial with Alhydrogel-adsorbed RiVax. Copyright © 2012, American Society for Microbiology. All Rights Reserved.

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Vitetta, E. S., Smallshaw, J. E., & Schindler, J. (2012). Pilot phase IB clinical trial of an alhydrogel-adsorbed recombinant ricin vaccine. Clinical and Vaccine Immunology, 19(10), 1697–1699. https://doi.org/10.1128/CVI.00381-12

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