ISOLATION OF SECONDARY METABOLITE COMPOUNDS FROM Elaeocarpus mastersii KING STEM BARK AND THEIR BIOLOGICAL ACTIVITY EVALUATION

Abstract

In this research, isolation of secondary metabolites of Elaeocarpus mastersii King stem bark was conducted by column chromatography and pure compounds were characterized by the IR, UV, and NMR spectra. The biological activity of the isolated compounds as antidiabetic was determined based on the α-glucosidase inhibition. The investigation led to isolate β-sitosterol (1), β-sitosterol glucoside (2), and cucurbitacin F(3). The evaluation of the α-glucosidase inhibitory assay showed that the isolated compounds had different inhibition performances caused by the interaction distinction with the active site of the enzyme. These results perform that Elaeocarpus mastersii King contained several types of secondary metabolite compounds and had the potential to be used as medicine.