Comparative Characterization of Gel Loaded Ketoprofen Nanosponges for Topical Delivery

Abstract

Nanosponges are tiny mesh-like nano porous particular structure in which a large variety of substances can be encapsulated or suspended, and then be incorporated into a dosage form. The aim of the present study was to develop and characterize an optimal stable nanosponges of Ketoprofen by emulsion solvent diffusion method using Ethyl Cellulose as polymer and Polyvinyl Alcohol as surfactant with different concentration and aimed to increase its bioavailability and release the drug in a controlled manner. Formulated nanosponges were evaluated for percentage yield, drug entrapment efficiency, surface morphology, particle size analysis and zeta potential. The FTIR spectra showed stable character of Ketoprofen in mixture of polymers and revealed the absence of drug polymer interactions. Selected F5 formulation showed, Percentage Yield (88 ± 0.16), %EE (86 ± 1.23%), Particle Size (320.7nm) and Zeta Potential of (-24.3mV) respectively and from SEM analysis its concluded that nanosponges are spherical, discrete with smooth surface. Best formulation F5 was loaded into the 1% carbopol 934 P gel which was evaluated for viscosity, spreadability, pH, drug content, in-vitro drug diffusion study, release kinetics, comparative study and stability studies. The release kinetics of the optimized formulation shows zero-order drug release. The stability study indicates no significant change in the in vitro diffusion profile of optimized formulation. Finally we concluded that prepared Ketoprofen nanosponge topical gel showed promising drug release and stability. Key words: Ketoprofen nanosponge, Topical gel, Zeta Potential, Zero order, Carbopol 934 P.