AB0995 Peculiarities of relationship between state of bone tissue and knee osteoarthritis in postmenopausal women

Abstract

Background The aim was to study the age-related particularity of relationship between structural-functional state of bone tissue and knee osteoarthritis (KO) in postmenopausal women. Objectives 175 postmenopausal women aged 50-79 years old with KO were examined, the control group consisted of 60 healthy women. Methods Bone state was measured by Dual-energy X-ray absorptiometry "Prodigy" (DXA), calcaneus quantitative ultrasound (QUS) denditomenty "Sahara",digital X-ray radiogrammetry (DXR) of the II-IV metacarpal bones (OSTIM+). Results We found the significant correlation between indices of QUS and presence and stage of KO in postmenopausal women. In patients with I stage of KO data were significantly higher compared with healthy women, but in patient with III stage of KO they were significantly lower (Stiffness index: 0 st. KO - 76.5+16.4; I - 83.6+15.9; II - 71.0+13.6; III - 67.8+14.1; F=4.33, d=0.005). Analysis of aging particularities showed that significant differences QUSdatawere in postmenopausal women aged 50-59 and 60-69 years old with knee osteoarthritis but were not in patients 70-79 years old. We did not found significant relationship between indices of DXA (lumbal spine, neck, total femur) and DXA and presence/stage KO, except bone mineral density (BMD) of total body and total spine. These indices were significantly higher in women with III stage of KO compared with healthy patients and women with early stages of osteoarthritis (0 st. KO - 0.90+0.12; I - 1.00+0.10; II - 1.01+0.15; III - 1.08+0.12 g/cm 2; F=7.31, d=0.0001). Conclusions Presence and stage of KO had significantly influence on QUS data, but not on DXA indices (lumbal spine, neck, total femur) and digital X-ray absorbtiometry.