Modification of Sesquiterpene Lactones—Dehydrocostus Lactone and Alantolactone—by Click Chemistry Method. Cytotoxic Activity of the Obtained Conjugates

Abstract

Abstract: A method for modifying sesquiterpene lactones using the click chemistry methodology has been developed. A series of conjugates of alantolactone and dehydrocostus lactone with alkoxy substituted benzylazides was obtained and their cytotoxic profile with respect to tumor cells of the A549, SH-SY5Y, Hep-2 and HeLa lines was evaluated. It has been shown that derivatives containing dehydrocostus lactone motif in their structure exhibit the highest cytotoxic activity.