ATF4‐amino acid circuits: a recipe for resistance in melanoma

Abstract

Lactate dehydrogenase A (LDHA) has appropriately received attention as a therapeutic target for the treatment of a broad spectrum of tumor types, yet little is known regarding intrinsic resistance to LDHA inhibitors. Pathria et al ([2018][1]) now establish that ATF4‐dependent control of enzymes that direct amino acid metabolism confers resistance to LDHA inhibitors in melanoma and identify chokepoints that can be exploited to overcome metabolic compensation, setting the stage for trials with such combinations. The EMBO Journal (2018) e100600 [1]: #ref-7