Molecular docking, drug-likeness, and ADMET study of 1-benzyl-3-benzoylurea and its analogs against VEGFR-2

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Abstract

In silico study was performed to predict the possibility of 1-benzyl-3-benzoylurea and 22 analogs as anticancer drug candidates, via VEGFR2 inhibition. Molecular docking studies against VEGFR2 receptor revealed that all of designed compounds have better score than the lead compound, of which three analogs (p-nitro, p-methoxy, and p-ethyl) were considered optimal among other compounds (

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Suhud, F., Tjahjono, D. H., Yuniarta, T. A., Putra, G. S., & Setiawan, J. (2019). Molecular docking, drug-likeness, and ADMET study of 1-benzyl-3-benzoylurea and its analogs against VEGFR-2. In IOP Conference Series: Earth and Environmental Science (Vol. 293). Institute of Physics Publishing. https://doi.org/10.1088/1755-1315/293/1/012018

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