Gap junction remodeling and cardiac arrhythmogenesis: Cause or coincidence?

Abstract

Gap junctions, clusters of transmembrane channels that link adjoining cells, mediate myocyte-to-myocyte electrical coupling and communication. The component proteins of gap junction channels are termed connexins and, in in vitro expression systems, gap-junctional channels composed of different connexin types exhibit different biophysical properties. In common with other tissues, the heart expresses multiple connexin isoforms. Spatially defined patterns of expression of three connexin isoforms - connexin43, connexin40 and connexin45 - form the cell-to-cell conduction pathways responsible for the orderly spread of current flow that governs the normal cardiac rhythm. Remodeling of gap junction organization and.connexin expression is a common feature of human heart disease, conditions-in-which-there is an arrhythmic-tendency.-This-remodeling may take the form of disturbances-in the cistribution:of gapjunctions_-and/or.quantitative_alterations in connexin expression, notably reduced ventricular connexin43 levels. The idea that such changes may contribute to the development of a pro-arrhythmic substrate in the diseased heart has gained ground over the last decade. Recent studies using transgenic mice models have raised new-opportunities to explore the significance of gap junction remodeling in the diseased heart.