Hepatocyte Growth Factor Enhances Engraftment and Function of Nonhuman Primate Islets

  • Fiaschi-Taesch N
  • Berman D
  • Sicari B
  • et al.
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Abstract

Adenoviral delivery of hepatocyte growth factor (HGF) to rodent islets improves islet graft survival and function, markedly reducing the number of islets required to achieve glucose control. Here, we asked whether these prior observations in rodent models extend to nonhuman primate (NHP) islets.

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Fiaschi-Taesch, N. M., Berman, D. M., Sicari, B. M., Takane, K. K., Garcia-Ocana, A., Ricordi, C., … Stewart, A. F. (2008). Hepatocyte Growth Factor Enhances Engraftment and Function of Nonhuman Primate Islets. Diabetes, 57(10), 2745–2754. https://doi.org/10.2337/db08-1085

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