Differential expression of cardiac troponin T and I in a patient with isolated skeletal muscular sarcoidosis

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Abstract

A 49-year-old female was referred to our hospital due to high serum creatine kinase (CK) (2,605 IU/L) and serum cardiac troponin T (cTnT) (0.342 ng/mL) levels. She had no other complaints and further examinations suggested no signs of cardiac disease. Additionally, the serum cardiac troponin I (cTnI) levels were normal. She reported having gradually felt difficulty in walking upstairs. A biopsy indicated skeletal muscle sarcoidosis with positive staining for cTnT. Steroid therapy immediately resolved her muscular symptoms with a normalization of the serum CK levels. Since the serum levels of cTnI were normal, the concomitant measurement of cTnT/cTnI might be useful to diagnose skeletal muscular disease biochemically in such cases.

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Mannoji, H., Hayashi, F., Kubota, T., Ikeda, Y., Ishibashi-Ueda, H., Kato, S., … Yamamoto, Y. (2016). Differential expression of cardiac troponin T and I in a patient with isolated skeletal muscular sarcoidosis. Internal Medicine, 55(21), 3215–3217. https://doi.org/10.2169/internalmedicine.55.6888

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