Automatic Identification of the Best Auscultation Area for the Estimation of the Time of Closure of Heart Valves through Multi-Source Phonocardiography

Abstract

In the latest years, multi-source phonocardiography (PCG) is gaining interest in relation to the home monitoring of cardiovascular diseases. An application of interest regards the monitoring of the time of closure of the four cardiac valves, which would enable the follow-up of at-risk patients for heart failure. In this work, we propose a hybrid system based on hierarchical clustering and Multi-Criteria Decision Analysis (MCDA) for automatically selecting the best auscultation area for the mentioned application through multi-source PCG. We simultaneously recorded 48 PCG signals from the subject's chest and divided them into morphologically homogenous groups using agglomerative hierarchical clustering, based on their correlation. Then, we explored three different approaches to select the best auscultation area, based respectively on the minimum latency, on the maximum signal-to-noise ratio, and on multiple criteria using ELECTRE III. The results obtained on the follow-up of a healthy subject over consecutive days show that a) the selection of the auscultation area using MCDA overcomes the limits of single-criteria approaches, b) the estimate of the time of closure of the heart valves using the proposed system is more robust than what obtained through the state-of-the-art single-source methodology.