Tranexamic Acid Use Intra-Operatively Decreases the Need for Blood Transfusions and Post-Operative Edema in Temporomandibular Joint Surgeries

Abstract

Temporomandibular joint (TMJ) surgeries cover a vast assortment of surgical procedures such as tooth extractions, tissue biopsies, and extensive maxillofacial surgeries. Major complications that occur during and after TMJ surgeries include uncontrolled bleeding, considerable blood loss, serious infections, and edema. Tranexamic acid (TXA) is an antifibrinolytic agent that reduces blood loss by inhibiting the enzymatic breakdown of fibrin. Currently, TXA is widely used in various orthopedic surgeries to reduce bleeding and decrease the need for blood transfusions. In this study, we observed five patients undergoing major TMJ replacement surgeries and administered TXA during the procedure. The principal aim of this study was to examine the association between TXA administration during TMJ replacement surgery and blood loss and tissue edema.