Synthesis, characterization and antimicrobial activity of diorganotin(IV) derivatives of some bioactive bifunctional tridentate Schiff base ligands

Abstract

Some new organotin(IV) complexes of the type R2Sn[OC(R'):CH(CH3)C:NR''O] (R = CH3, C4H9, C6H5; R' = CH3, C6H5; and R'' = (CH2)2, (CH2)3) have been synthesized by the reactions of diorganotin dichloride with the sodium salt of the corresponding bifunctional tridentate Schiff base ligands in unimolar ratio in refluxing tetrahydrofuran (THF). All these compounds have been characterized by elemental analyses, and their probable structures, in which the central tin atom is pentacoordinated, have been proposed on the basis of infrared (IR) and 1H, 13C and 119Sn NMR and fast atom bombardment mass spectroscopic studies. The ligands, metal precursors and their corresponding diorganotin complexes have also been screened for antimicrobial activities.