Clinical development of malaria vaccine

Abstract

Malaria is one of the most serious infectious disease in tropical and subtropical regions. Despite tremendous scientific efforts, an effective malaria vaccine has not yet been realized and remains an elusive goal. Here, we review recent clinical trials of candidate vaccines including our SE36 malaria vaccine as well as our second generation vaccine which combines CpG adjuvant, that was recently identified to stimulate innate immunity and protective epitopes in SE36 molecule.