FENUGREEK TREATMENT OF POLYCYSTIC OVARIAN SYNDROME: AN IN-SILICO EVALUATION TO EXPLORE THE THERAPEUTIC EFFICACY OF QUERCETIN

Abstract

Background:Polycystic ovarian syndrome(PCOS)is a fairly common condition that affects both endocrine and metabolic systems. It affects women of reproductive age of all ethnicity and race. Only a small number of females are diagnosed with it.There is a good percentage of people who are still not diagnosed because of a lack of good diagnostic criteria and varying symptoms among different individuals.Fenugreek is an herb that contains many constituents including Quercetin. It helps in the regulation of steroidogenesis.Material and Methods: Molecular docking of Quercetin with insulin receptor substrate 1, follicle-stimulatinghormone receptor and androgen receptor wasperformed using Autodock4. The ADME (absorption, distribution, metabolism and excretion) properties were calculated by using smile notation in the Swiss ADME web-based tool. The Bioavailability Score was calculated using Mol-inspiration web-based tool.Results: The study shows that Quercetin is having best binding capacity with the androgen receptor and also shows good binding affinity with FSH receptors and Insulin receptors.This indicates Quercetin can have a positive effect on PCOS.Conclusion: We can concludethat Quercetin is helpful for the treatment of PCOS. KeyWords: Quercetin, Polycystic ovarian syndrome, Diabetes mellitus